Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prospects of DNA nanotechnology in stroke repair and regeneration.

Communications biology·2026

Same author

Nanocomplex-Integrated Multifunctional Hydrogel for Fast-Tracked Wound Repair Application: A Preclinical Evaluation.

ACS applied bio materials·2026

Same author

Surface-Engineered Smart Carbon Quantum Dots at the Brain Interface for Neurotherapeutics and Brain Imaging: From Surface to Synapse.

Analytical chemistry·2026

Same author

Rationally designed mitochondria-impairing small molecule-enabled chemo-phototherapy to potentiate apoptosis and autophagy in cancer cells.

Journal of materials chemistry. B·2026

Same author

AI-Driven Design and Clinical Translation of Nucleotide-Peptide and Peptide-Drug Conjugates.

ACS biomaterials science & engineering·2026

Same author

Polyaniline-integrated composite hydrogel network with antioxidant defense, bacterial clearance and In vivo tissue regeneration.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: Jun 21, 2025

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

DNA functionalized programmable hybrid biomaterials for targeted multiplexed applications.

Nihal Singh¹, Ankur Singh¹, Mukesh Dhanka¹

¹Discipline of Bioengineering, Indian Institute of Technology Gandhinagar, Gujarat, India, 382355. dhiraj.bhatia@iitgn.ac.in.

Journal of Materials Chemistry. B

|July 8, 2024

Summary

DNA nanotechnology enables complex DNA biomaterials, but limitations are overcome by DNA-based hybrid materials. These advanced materials offer broad applications in biomedicine and nanodevices.

More Related Videos

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Related Experiment Videos

Last Updated: Jun 21, 2025

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Area of Science:

Biomaterials Science
Nanotechnology
Molecular Engineering

Background:

DNA nanotechnology allows programmable DNA structure design via Watson-Crick base-pairing.
Traditional DNA-based materials face challenges in scalability, mechanical properties, cost, and stability.
DNA-based hybrid biomaterials integrate DNA with functional materials to address these limitations.

Purpose of the Study:

To review recent advancements in DNA-based hybrid biomaterials.
To provide an in-depth understanding of molecular design principles, functionalities, and applications.
To discuss current challenges and future prospects in the field.

Main Methods:

Literature review of recent research on DNA-based hybrid materials.
Analysis of molecular design strategies for conjugating DNA with functional materials.
Synthesis and characterization of DNA-based hybrid materials (as reported in literature).

Main Results:

DNA-based hybrid materials demonstrate enhanced properties compared to traditional DNA materials.
Successful conjugation of DNA with various functional materials has been achieved.
Diverse applications in biomedicine, clinical diagnostics, and nanodevices are emerging.

Conclusions:

DNA-based hybrid materials represent a significant advancement in biomaterials.
Overcoming limitations of DNA materials opens new avenues for biological applications.
Continued research is crucial to address challenges and realize the full potential of these materials.