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Related Experiment Videos

Abnormal skin development in pupoid foetus (pf/pf) mutant mice.

C Fisher, E J Kollar

    Journal of Embryology and Experimental Morphology
    |June 1, 1985
    PubMed
    Summary

    The pupoid foetus (pf/pf) mutation in mice causes dermal cells, including nerves and blood vessels, to invade the epidermis, disrupting its structure. A basal lamina consistently separates these invading cells from the epidermis.

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    Area of Science:

    • Developmental biology
    • Cell biology
    • Dermatology

    Background:

    • The pupoid foetus (pf/pf) mutation affects mouse development.
    • Epidermal structure and integrity are crucial for skin function.

    Purpose of the Study:

    • To investigate the cellular and structural changes in the epidermis of mice with the pupoid foetus (pf/pf) mutation.
    • To characterize the nature of the invading cells and their interaction with the epidermis.

    Main Methods:

    • Histological analysis of mouse embryos at different developmental stages (13, 16, and 19 days).
    • Immunofluorescence staining for fibronectin and laminin.
    • Ultrastructural examination.

    Main Results:

    • Mutant epidermis shows variable thickness and invasion by dermal cells starting at 16 days.
    • Invading cells include nerve fibers, Schwann cells, blood vessels, and fibronectin-secreting cells.
    • A basal lamina, identified by laminin, consistently separates the epidermis from the invading cell population.

    Conclusions:

    • The pupoid foetus (pf/pf) mutation leads to significant disruption of epidermal development due to dermal cell invasion.
    • The persistent basal lamina suggests a specific barrier mechanism despite the abnormal cellular infiltration.

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