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Updated: Jun 21, 2025

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Association between Benign Paroxysmal Positional Vertigo and Thyroid Diseases: Systematic Review and Meta-Analysis.

Cyntia Machado Lima1, Daniel Felipe Fernandes Paiva2, Ana Paula Corona3

  • 1Postgraduate Program in Health Sciences, Faculty of Medicine, Universidade Federal da Bahia, Salvador, BA, Brazil.

International Archives of Otorhinolaryngology
|July 8, 2024
PubMed
Summary
This summary is machine-generated.

Benign paroxysmal positional vertigo (BPPV) is common, but its causes are unclear. This study found a significant link between Hashimoto thyroiditis and BPPV, though not with hypothyroidism.

Keywords:
benign paroxysmal positional vertigohashimoto thyroiditishyperthyroidismhypothyroidism

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Area of Science:

  • Otolaryngology
  • Endocrinology
  • Epidemiology

Background:

  • Benign paroxysmal positional vertigo (BPPV) is a prevalent peripheral vestibular disorder with incompletely understood etiopathogenesis.
  • Thyroid diseases are increasingly recognized as potential contributing factors to BPPV.
  • Investigating these associations is crucial for understanding BPPV's diverse origins.

Purpose of the Study:

  • To systematically review and meta-analyze epidemiological studies examining the association between BPPV and thyroid diseases.
  • To determine if specific thyroid conditions, such as hypothyroidism and Hashimoto thyroiditis, are linked to BPPV.

Main Methods:

  • A systematic review and meta-analysis of studies from PubMed, Web of Science, Embase, Cochrane Library, and Scopus.
  • Included studies investigated the association between BPPV and thyroid diseases.
  • Meta-analysis utilized a dichotomous model with Mantel-Haenszel statistics, odds ratio (OR), and 95% confidence interval (CI).

Main Results:

  • Seven studies met systematic review criteria; four provided data for meta-analysis.
  • Qualitative analysis indicated studies were from Europe and Asia, predominantly case-control designs.
  • Meta-analysis found no association between hypothyroidism and BPPV, but a statistically significant relationship between Hashimoto thyroiditis and BPPV.

Conclusions:

  • The meta-analysis suggests a potential association between BPPV and Hashimoto thyroiditis.
  • Further research is necessary to confirm and elucidate the observed relationship.
  • Understanding this link may offer new insights into BPPV etiopathogenesis.