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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
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Biomaterials for extrusion-based bioprinting and biomedical applications
Arianna Rossi1, Teresa Pescara2, Alberto Maria Gambelli3
1Smart Manufacturing Laboratory, Engineering Department, University of Perugia, Perugia, Italy.
Frontiers in Bioengineering and Biotechnology
|July 8, 2024
Summary
Material extrusion bioprinting is popular for tissue fabrication due to its low cost and cell-friendly nature. Key challenges include achieving high resolution and accuracy while maintaining cell viability during extrusion.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Bioprinting Technologies
Background:
- Material extrusion bioprinting is increasingly favored for tissue and organ fabrication.
- Its popularity stems from accessibility, low cost, and avoidance of cell-damaging energy sources like lasers.
- Emerging applications highlight its potential in the biomedical field.
Purpose of the Study:
- To provide an overview of extrusion-based bioprinting technologies and bioink materials.
- To discuss the primary challenges in achieving resolution and accuracy in extrusion bioprinting.
- To explore methods for ensuring cell viability and function during the bioprinting process.
Main Methods:
- Review of current extrusion-based bioprinting technologies.
- Analysis of different bioink material families used in extrusion bioprinting.
- Discussion of challenges related to resolution, accuracy, and cell survival.
Main Results:
- Extrusion bioprinting offers advantages but faces challenges in resolution, accuracy, and speed.
- Cell viability and function are critical concerns due to shear stress during extrusion.
- Achieving microscale features, like vascularization, requires overcoming these technical hurdles.
Conclusions:
- Material extrusion bioprinting is a promising technology for tissue fabrication.
- Addressing challenges in resolution, accuracy, and cell viability is crucial for advancing applications.
- Further research is needed to optimize techniques for complex tissue engineering.
