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Exploratory bibliometric analysis and text mining to reveal research trends in cardiac aging
Takahiro Kamihara1, Ken Tanaka2, Takuya Omura3
1Department of Cardiology National Center for Geriatrics and Gerontology Obu Japan.
Insights
Cardiac aging involves mitochondrial dysfunction, oxidative stress, and impaired autophagy, particularly mitophagy. Research shows autophagy and mitophagy are increasingly recognized as key factors in cardiac aging mechanisms.
Area of Science:
- Cardiology
- Gerontology
- Molecular Biology
Background:
- Cardiac aging is a complex physiological process.
- Understanding its mechanisms is crucial for geriatric health.
- Previous research has identified several contributing factors.
Purpose of the Study:
- To analyze 40 years of literature on cardiac aging.
- To identify key mechanisms and terms associated with cardiac aging.
- To understand the current research landscape and emerging trends.
Main Methods:
- Text mining analysis of PubMed literature.
- Utilized multiple text mining and machine learning tools.
- Extracted and analyzed frequently occurring terms related to cardiac aging.
Main Results:
- Key terms include diastolic dysfunction, hypertrophy, fibrosis, apoptosis, mitochondrial dysfunction, oxidative stress, and autophagy.
- Autophagy, and specifically mitophagy, are increasingly prominent in recent cardiac aging research.
- Mitochondrial dysfunction and oxidative stress are central to cardiac aging.
Conclusions:
- Cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impaired autophagy, especially mitophagy.
- Autophagy and mitophagy represent significant breakthroughs in understanding cardiac aging.
- Further research is needed to develop strategies to mitigate cardiac aging effects.
Objectives:
We conducted a text mining analysis of 40 years of literature on cardiac aging from PubMed to investigate the current understanding on cardiac aging and its mechanisms. This study aimed to embody what most researchers consider cardiac aging to be.
Methods:
We used multiple text mining and machine learning tools to extract important information from a large amount of text.
Results:
Analysis revealed that the terms most frequently associated with cardiac aging include "diastolic," "hypertrophy," "fibrosis," "apoptosis," "mitochondrial," "oxidative," and "autophagy." These terms suggest that cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. We also revealed an increase in the frequency of occurrence of "autophagy" in recent years, suggesting that research on autophagy has made a breakthrough in the field of cardiac aging. Additionally, the frequency of occurrence of "mitophagy" has increased significantly since 2019, suggesting that mitophagy is an important factor in cardiac aging.
Conclusions:
Cardiac aging is a complex process that involves mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. Further research is warranted to elucidate the mechanisms of cardiac aging and develop strategies to mitigate its detrimental effects.
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