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Updated: Jun 21, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

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Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments

Amir Saamaan Fattahi1, Mahboobeh Jafari2, Ghazal Farahavar2

  • 1Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Critical Reviews in Oncology/Hematology
|July 8, 2024
PubMed

Insights

Immunoconjugates show promise for cancer therapy by targeting tumor cells. This review explores how targeting the tumor microenvironment (TME) with advanced immunoconjugates can improve treatment efficacy.

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Immunoconjugates combine antibodies with agents like drugs or toxins to target cancer cells.
  • The tumor microenvironment (TME) presents a significant challenge to effective cancer therapy due to its complexity.
  • Understanding TME interactions is crucial for developing successful immunoconjugate-based treatments.

Purpose of the Study:

  • To review the role of the tumor microenvironment (TME) in cancer therapy using immunoconjugates.
  • To examine recent advancements in TME-targeted immunoconjugates and their strategies.
  • To discuss various antibody types and immunoconjugate applications in cancer immunotherapy.

Main Methods:

  • Comprehensive literature review on TME-targeted immunoconjugates.
  • Analysis of antibody engineering, combination therapies, and nanotechnology applications.
  • Evaluation of immunoconjugate mechanisms, advantages, limitations, and clinical relevance.

Main Results:

  • TME components significantly influence immunoconjugate efficacy.
  • Diverse antibody strategies (neutralizing, checkpoint inhibitors, bispecific) are employed to target TME.
  • Emerging technologies enhance immunoconjugate safety and therapeutic potential.

Conclusions:

  • TME-targeted immunoconjugates represent a promising frontier in cancer immunotherapy.
  • Further research and technological advancements are essential for optimizing these therapies.
  • Future developments focus on enhancing specificity, efficacy, and safety of immunoconjugates against cancer.
Keywords:
TMEantibodycancer immunotherapyimmunoconjugatestargeting

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