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Updated: Jun 21, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
A Comprehensive Review: Pharmacogenomics and Personalized Medicine Customizing Drug Therapy Based on Individual
Biswajit Dash1, Murshidha Shireen2, Pushpendra3
1Amity Institute of Pharmacy, Amity University-Kolkata, 700135, West Bengal, India.
Genetic personalization of drug response, using pharmacogenetics and pharmacogenomics, enhances medication efficacy and safety. Understanding the human genome
Area of Science:
- Pharmacogenomics and Personalized Medicine
- Genetics and Drug Response
Background:
- Individual drug responses are influenced by genetics, environment, and illness.
- Pharmacogenetics and pharmacogenomics investigate the genetic basis of drug response.
Purpose of the Study:
- To understand the genetic personalization of drug response.
- To improve drug efficacy and safety through personalized medicine.
Main Methods:
- Studying single genes (pharmacogenetics) and multiple genes (pharmacogenomics).
- Investigating genotype-phenotype associations.
- Conducting clinical investigations for therapeutic relevance.
Main Results:
- Research has improved understanding of the genetic basis for individual medication responses.
- Pharmacogenomics leverages human genome diversity to predict drug response.
Conclusions:
- Pharmacogenomics holds significant potential for personalized therapeutic applications.
- Translational research is key to integrating pharmacogenomics into clinical practice.
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