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[Cefmenoxime diffusion into cerebrospinal fluid during human purulent meningitis]
Pathologie-Biologie
|May 1, 1985
Abstract:
We treated 10 patients with bacterial meningitis by 150 mg/kg/day cefmenoxime divided into six intravenous infusions. CSF samples were taken one hour after an IV on the second and fifth days. CSF cefmenoxime determined by microbiologic assay was 8.3 mg/l on days 2 and 5. Every patient recovered without sequelae. In our opinion, these results may support use of cefmenoxime in bacterial meningitis.
Insights
Cefmenoxime effectively treated bacterial meningitis in 10 patients, achieving high cerebrospinal fluid (CSF) concentrations. All patients recovered fully, suggesting cefmenoxime
Area of Science:
- Infectious Diseases
- Pharmacology
- Neuroscience
Context:
- Bacterial meningitis poses a significant threat, necessitating effective antibiotic treatments.
- Cerebrospinal fluid (CSF) penetration is crucial for antibiotics targeting central nervous system infections.
Purpose:
- To evaluate the efficacy and safety of cefmenoxime in treating bacterial meningitis.
- To determine cefmenoxime concentrations in CSF following intravenous administration.
Summary:
- Ten patients with bacterial meningitis received intravenous cefmenoxime (150 mg/kg/day).
- CSF cefmenoxime levels were measured via microbiologic assay on days 2 and 5, averaging 8.3 mg/L.
- All patients achieved complete recovery without any neurological sequelae.
Impact:
- The findings support the potential use of cefmenoxime as a treatment option for bacterial meningitis.
- Demonstrates favorable CSF penetration and therapeutic outcomes for cefmenoxime in meningitis patients.