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[Cefmenoxime diffusion into cerebrospinal fluid during human purulent meningitis]
Pathologie-Biologie
|May 1, 1985
Summary
Cefmenoxime effectively treated bacterial meningitis in 10 patients, achieving high cerebrospinal fluid (CSF) concentrations. All patients recovered fully, suggesting cefmenoxime
Area of Science:
- Infectious Diseases
- Pharmacology
- Neuroscience
Context:
- Bacterial meningitis poses a significant threat, necessitating effective antibiotic treatments.
- Cerebrospinal fluid (CSF) penetration is crucial for antibiotics targeting central nervous system infections.
Purpose:
- To evaluate the efficacy and safety of cefmenoxime in treating bacterial meningitis.
- To determine cefmenoxime concentrations in CSF following intravenous administration.
Summary:
- Ten patients with bacterial meningitis received intravenous cefmenoxime (150 mg/kg/day).
- CSF cefmenoxime levels were measured via microbiologic assay on days 2 and 5, averaging 8.3 mg/L.
- All patients achieved complete recovery without any neurological sequelae.
Impact:
- The findings support the potential use of cefmenoxime as a treatment option for bacterial meningitis.
- Demonstrates favorable CSF penetration and therapeutic outcomes for cefmenoxime in meningitis patients.