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Pharmabiotic/phytobiotic formulas approach and their intravaginal effect on different parameters
María Hortencia Miranda1, María Elena Fátima Nader-Macías2
1Centro de Referencia para Lactobacilos, CONICET. Chacabuco 145, San Miguel de Tucumán, CP4000, Tucumán, Argentina.
Veterinary Research Communications
|July 9, 2024
Summary
Probiotic and phytobiotic formulas containing lactic acid bacteria effectively prevent postpartum reproductive infections in cows. These safe, long-lasting formulations support beneficial bacteria and reduce harmful ones, offering an alternative to antibiotics.
Area of Science:
- Veterinary Medicine
- Microbiology
- Animal Health
Background:
- Postpartum reproductive infections in cows cause significant economic losses.
- Antibiotic therapy is a common treatment but raises concerns about resistance.
- Lactic acid bacteria (LAB) offer a potential alternative for preventing and treating these infections.
Purpose of the Study:
- To design and assess the long-term viability and safety of probiotic and phytobiotic formulations for bovine reproductive health.
- To evaluate the impact of these formulations on the native vaginal microbiota in pregnant cows.
- To determine the efficacy of LAB-based treatments in preventing postpartum infections.
Main Methods:
- Selected lactic acid bacteria were incorporated into probiotic/phytobiotic formulas with plant extracts.
- Formulations were administered intravaginally to pregnant cows pre- and postpartum.
- Microbiota changes, bacterial colonization, and safety parameters (nutritional, clinical, hematological, biochemical) were assessed.
Main Results:
- The microorganisms maintained viability for up to 9 months under refrigeration.
- Enterobacteriaceae increased postpartum, except in cows treated with LAB + vegetable extract.
- LAB numbers significantly increased in all treated groups postpartum, indicating successful colonization.
- Safety parameters confirmed the formulations were harmless, with no adverse effects.
Conclusions:
- Probiotic and phytobiotic formulations containing lactic acid bacteria are viable and safe for preventing bovine postpartum reproductive infections.
- These formulations modulate the vaginal microbiota, promoting beneficial bacteria and inhibiting pathogens.
- LAB-based treatments represent a promising antibiotic-free strategy for improving reproductive health in cattle.
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