Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating cancer risk profiles in lung transplant recipients.

Translational lung cancer research·2026
Same author

Maximizing Lung Transplant Donor Utilization: Developing a Lobar Donor Repository Guided by Chest Computed Tomography Visual Scoring.

Interdisciplinary cardiovascular and thoracic surgery·2025
Same author

Impact of Mild-to-Moderate Donor Lung Infiltration on Post-lung Transplant Survival Outcomes and Risk Factors: A National Cohort Study.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2025
Same author

Impact of Age Difference Between Donor and Recipient on Intermediate- and Long-Term Survival in Lung Transplant Recipients: A Cohort Study Based on Recipient Age Stratification.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2025
Same author

Survival outcomes and risk factors after lung transplantation in patients with pre-transplant malignancy: a national cohort study.

Translational lung cancer research·2025
Same author

Survival and early outcomes following lung transplantation for interstitial lung disease associated with non-scleroderma connective tissue disease: a national cohort study.

Clinical and experimental rheumatology·2025

Related Experiment Video

Updated: Jun 21, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.4K

Lobar lung transplantation in the mouse.

Jiang Shi1, Caikang Luo1, Yu Xu1

  • 1Department of Thoracic Surgery and Oncology, State Key Laboratory and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Journal of Thoracic Disease
|July 10, 2024
PubMed
Summary

A new mouse model for lobar lung transplantation (LTx) was developed, improving donor organ utilization. This model shows comparable graft function and pathology to standard orthotopic LTx, offering a viable preclinical tool.

Keywords:
Mouselobar lung transplantation (lobar LTx)model

More Related Videos

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging
04:16

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Published on: April 19, 2024

966
A Heterotopic Mouse Model for Studying Laryngeal Transplantation
14:15

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

2.8K

Related Experiment Videos

Last Updated: Jun 21, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.4K
Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging
04:16

Author Spotlight: Advancing Lung Transplant Immunology Through Intravital Imaging

Published on: April 19, 2024

966
A Heterotopic Mouse Model for Studying Laryngeal Transplantation
14:15

A Heterotopic Mouse Model for Studying Laryngeal Transplantation

Published on: January 13, 2023

2.8K

Area of Science:

  • Surgical Innovation
  • Transplantation Research
  • Animal Models

Background:

  • Clinical lobar lung transplantation (LTx) requires a stable animal model.
  • Current orthotopic left LTx models discard the donor's right lung, leading to resource wastage.
  • A novel mouse model for lobar LTx is needed to address these limitations.

Purpose of the Study:

  • To introduce and validate a novel mouse model for lobar lung transplantation (LTx).
  • To assess the feasibility and efficacy of this new lobar LTx model.
  • To enhance the utilization rate of donor organs in experimental transplantation.

Main Methods:

  • Performed lobar and orthotopic left LTx in syngeneic mouse strains.
  • Assessed graft function using micro-computed tomography and arterial blood gases 28 days post-transplant.
  • Evaluated pathological changes via Hematoxylin-eosin and Masson's trichrome staining.

Main Results:

  • Achieved a 90% success rate for lobar LTx and 100% for orthotopic left LTx.
  • Graft preparation time was longer for lobar LTx (42.11±3.79 min) vs. orthotopic left LTx (30.10±3.14 min; P<0.001).
  • Graft function and histopathology were comparable between lobar and orthotopic left LTx at 28 days.

Conclusions:

  • Successfully developed a mouse model for lobar lung transplantation (LTx).
  • This model offers a potential preclinical platform for clinical lobar LTx.
  • The novel model addresses resource wastage associated with current orthotopic left LTx techniques.