Related Experiment Video
Updated: Jan 11, 2026
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
Impact of Mild-to-Moderate Donor Lung Infiltration on Post-lung Transplant Survival Outcomes and Risk Factors: A
Junjie He1, Caikang Luo2,3, Xiaoqing Lan1
1First Clinical College, Guangzhou Medical University, Guangzhou 510182, China.
Objectives:
Amid donor shortages, chest X-ray (CXR) is widely used for lung donor screening due to its accessibility, low cost, and rapid imaging. We evaluated the impact of donor CXR infiltrates on post-transplant survival to inform donor lung utilization.
Methods:
This retrospective cohort study included adult lung transplant recipients from the United Network for Organ Sharing (UNOS) registry from May 5, 2005 to December 31, 2022. Patients were grouped by the presence or absence of donor CXR infiltrates. Using propensity score matching (PSM) to control variable balance, Kaplan-Meier survival analysis estimated post-transplant survival (at 30 days, 90 days, 1 year, 5 years, and 10 years). Multivariable logistic regression models were applied to identify independent risk donor factors of CXR infiltration.
Results:
Unadjusted analyses showed higher short-term survival (30-day/90-day/1-year) in the presence of chest X-ray infiltration group (PCIG) versus the absence of chest X-ray infiltration group (ACIG) (all P < .05), but no differences in 5-year/10-year survival (P > .05) or median survival (P = .567). After PSM, the 2 groups had similar recipient causes of death and rates of postoperative complications. Obesity, prior pulmonary infection, ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2)<300 mmHg, and positive bronchoscopy independently predicted donor infiltrates (all P < .001).
Conclusions:
Mild-to-moderate donor lung CXR infiltrates do not independently impair long-term survival or increase major complications. These findings support rational utilization of such lungs within standardized multivariable assessment.
