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Breast calcifications on mammography from systemic amyloidosis: A case report
Joanna Rossi1, Rebecca Wingfield1, Ashley Cimino-Mathews1
1Johns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD 21287, USA.
Radiology Case Reports
|July 10, 2024
Summary
Mammography calcifications can signal systemic diseases like amyloidosis. This case highlights how recognizing light chain amyloidosis (AL) led to a correct diagnosis via core biopsy and Congo red staining.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Mammographic calcifications can arise from systemic diseases, sometimes mimicking malignancy.
- Histologic sampling is crucial for differentiating benign calcifications from malignant lesions.
Observation:
- A case presented with new bilateral mammographic calcifications.
- The patient had a known diagnosis of systemic light chain amyloidosis (AL).
Findings:
- Core biopsy revealed amyloidosis.
- Congo red staining confirmed the histologic diagnosis of amyloidosis.
- The mammographic calcifications were attributed to systemic amyloidosis.
Implications:
- Systemic diseases can mimic malignant findings on mammography.
- Awareness of systemic conditions aids in accurate diagnosis.
- Radiology-pathology correlation is vital for managing patients with systemic diseases presenting with mammographic abnormalities.
Keywords:
AmyloidosisBreast calcificationsCongo redLight chain (AL) amyloidosisMammographySystemic amyloidosisMore Related Videos
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