Post-COVID-19: Hematological Factors Changes in Patients at Three-time Intervals

Area of Science:

• Hematology
• Infectious Diseases
• COVID-19 Research

Background:

• Hematological parameters are critical indicators of disease severity and pathogenesis.
• COVID-19 significantly impacts various physiological systems, necessitating detailed monitoring.

Purpose of the Study:

• To evaluate hematological factors across different COVID-19 severity stages.
• To assess changes in these factors at distinct time intervals post-infection.

Main Methods:

• Analyzed serum samples from 470 COVID-19 patients (moderate, severe, critical).
• Collected samples at 1st day, 1 month, and 3 months post-onset.
• Measured complete blood count (CBC) parameters, hemoglobin, hematocrit, hsCRP, G6PD deficiency, and hemoglobinopathies.

Main Results:

• Significant alterations in WBC, neutrophil, lymphocyte, platelet, RBC, Hb, HCT, MCV, MCH, and hsCRP levels correlated with disease severity (p<0.0001).
• WBC and RBC parameters showed significant changes over time intervals (p<0.0001), excluding monocytes and eosinophils.
• Hematological and hsCRP levels varied significantly by gender and correlated with age and BMI (p<0.0001).

Conclusions:

• Hematological and inflammatory markers differ significantly based on COVID-19 severity, time, and gender.
• These findings underscore the importance of monitoring hematological parameters during and after COVID-19 infection for effective patient management.