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Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

Siyuan Cheng1,2,3, Ivan Fan Xia1,2,3, Renate Wanner1,2,3

  • 1Department of Genetics, Yale School of Medicine, New Haven, United States.

Elife
|July 10, 2024
PubMed
Summary

Blood flow guides vascular smooth muscle cell (VSMC) differentiation on brain arteries. Endothelial KLF2a activation by flow initiates this crucial process for cerebrovascular development and health.

Keywords:
artery muscularizationbrain artery developmentcircle of Willisdevelopmental biologyflow hemodynamicsvascular smooth muscle cell differentiationzebrafish

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