[Cold plasma in wound healing]

Area of Science:

• Biomedical Engineering
• Dermatology
• Wound Care

Background:

• Chronic wounds present significant patient burdens and healthcare costs.
• Current treatments are often lengthy and insufficient for complete healing.
• Innovative therapies like cold plasma are gaining attention for wound management.

Purpose of the Study:

• To evaluate the efficacy of cold plasma as an adjunctive wound healing therapy.
• To understand the mechanisms of action of cold plasma in wound healing.
• To assess the current evidence base for cold plasma in wound treatment.

Main Methods:

• Review of existing literature on cold plasma for wound healing.
• Analysis of studies investigating cold plasma's effects on bacterial cells, epithelial cells, and endothelial cells.
• Examination of cold plasma's impact on angiogenesis and cellular oxygen metabolism.

Main Results:

• Cold plasma components, including electromagnetic radiation and free radicals, exhibit antimicrobial properties.
• Positive interactions with epithelial and endothelial cells promote wound healing.
• Stimulation of angiogenesis and cellular oxygen metabolism observed.

Conclusions:

• Cold plasma therapy demonstrates potential for improving wound healing outcomes.
• Evidence suggests benefits in bacterial reduction and cellular regeneration.
• Further high-quality research is necessary to establish a robust evidence base and clinical guidelines.