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A Case Series Depicting PSMA Expression in Nonmalignant Lesions
Suchismita Ghosh1, Archi Agrawal1, Sayak Choudhury1
1Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment, Research and Education in Cancer and Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Summary
Prostate-specific membrane antigen (PSMA) imaging is crucial for prostate cancer staging. This study highlights common benign conditions that can cause false-positive PSMA uptake, aiding accurate diagnosis.
Area of Science:
- Nuclear medicine
- Oncology
- Radiology
Background:
- Prostate-specific membrane antigen (PSMA) is a key biomarker for prostate cancer detection and staging.
- PSMA is expressed in prostate cancer cells and normal prostatic tissue, but also in some nonprostatic cells.
- Ambiguous PSMA uptake in benign lesions can complicate diagnosis.
Observation:
- This case series examines incidental PSMA uptake in common benign conditions.
- The study focuses on situations where PSMA imaging might lead to misinterpretation.
- Examples of benign conditions with PSMA uptake are presented.
Findings:
- False-positive PSMA uptake in nonmalignant lesions can occur.
- Understanding these benign mimics is essential for accurate interpretation of PSMA scans.
- Histopathological correlation and follow-up imaging are vital for clinical decision-making.
Implications:
- Improved diagnostic accuracy in prostate cancer staging and recurrence detection.
- Reduced unnecessary follow-up or interventions due to false-positive findings.
- Enhanced clinical decision-making by recognizing benign PSMA-avid lesions.
