PET/CT Normal Variants and Pitfalls in Paediatric Disorders

18F- Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) has become an indispensable imaging modality in the evaluation of paediatric malignancies as well selected infectious and inflammatory disorders. However, the interpretation of paediatric PET/CT is often challenging because of age-dependent physiological tracer distribution, developmental changes, therapy-related alterations and technical artifacts that can mimic disease. Familiarity with normal variants and potential pitfalls specifically seen in paediatric imaging, together with careful corelation of PET findings with CT morphology and clinical history, is essential for accurate image interpretation. This review summarizes the spectrum of physiological FDG uptake patterns, common interpretative pitfalls and practical strategies to improve diagnostic confidence and avoid unnecessary repeat investigations in paediatric PET/CT imaging.