Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer.

Nature communications·2026

Same author

Cellular nucleic acid-binding protein (CNBP) dependent cytokine programming shapes host defense against <i>Plasmodium</i> infection.

bioRxiv : the preprint server for biology·2026

Same author

Licensed to pore: Gasdermins in action.

Cell chemical biology·2026

Same author

Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Nature immunology·2026

Same author

Lymph node-targeted DNA engages TBK1/IFN-I-driven innate immunity to induce potent T cell responses and durable memory in mice and NHPs.

Science advances·2026

Same author

Endothelial cell expression of STING<sup>V154M</sup>: Gain-of-function mutation delays the resolution of UVB-induced skin injury.

The Journal of investigative dermatology·2026

Search research articles

Related Experiment Video

Updated: Jun 21, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Unmasking immune suppression.

Jason R Pitarresi¹, Katherine A Fitzgerald²

¹Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Science (New York, N.Y.)

|July 11, 2024

Summary

Inhibiting a mutated metabolic enzyme can restore the effectiveness of antitumor immunity. This approach re-enables the immune system to fight cancer more effectively.

Area of Science:

Immunology
Metabolic pathways
Cancer research

Background:

Cancer cells often evade immune surveillance by altering metabolic pathways.
Mutated metabolic enzymes can contribute to tumor growth and immune suppression.

Purpose of the Study:

To investigate the potential of targeting a specific mutated metabolic enzyme.
To determine if inhibiting this enzyme can restore antitumor immune responses.

Main Methods:

Utilized genetically engineered mouse models with specific cancer mutations.
Employed pharmacological inhibitors to target the mutated metabolic enzyme.
Assessed immune cell infiltration and activity within tumors using flow cytometry and immunohistochemistry.

Main Results:

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Related Experiment Videos

Last Updated: Jun 21, 2025

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Inhibition of the mutated metabolic enzyme led to significant reduction in tumor growth.
Restored infiltration and activation of cytotoxic T lymphocytes within the tumor microenvironment.
Decreased expression of immunosuppressive factors by tumor cells.

Conclusions:

Targeting mutated metabolic enzymes represents a viable strategy to enhance antitumor immunity.
Restoring immune recognition and attack against cancer cells is achievable through metabolic enzyme inhibition.