Microbiota alert: Proteobacteria consume arginine to dampen omental antitumor immunity
Xian Du1, Zuliang Jie2, Qiang Zou1
1Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, China.
Cell Host & Microbe
|July 11, 2024
Abstract:
The microbiota can impact antitumor immunity, but whether the microbiota regulates omental antitumor immunity remains elusive. In this issue of Cell Host & Microbe, Meza-Perez et al. demonstrated that Proteobacteria consume arginine to increase Treg cell suppressive capacity and inhibit antitumor immune responses, promoting tumor growth in the omentum.
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