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Related Experiment Video

Updated: May 11, 2026

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Triple Aspiration versus Conventional Aspiration Techniques: A Randomized In Vitro Evaluation.

Cem Bilgin1, Jiahui Li2, Esref Alperen Bayraktar3

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AJNR. American Journal of Neuroradiology
|July 11, 2024
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Summary

The triple aspiration technique significantly improves first-pass efficacy (FPE) and vacuum pressure during aspiration thrombectomy compared to single aspiration. This method may enhance clot removal success in thrombectomy procedures.

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Area of Science:

  • Endovascular therapy
  • Cerebrovascular disease management
  • Interventional neurology

Background:

  • Aspiration thrombectomy is a standard treatment for ischemic stroke.
  • Single-aspiration maneuvers are common, but multiple cycles may improve outcomes.
  • The efficacy of a triple aspiration technique has not been extensively studied.

Purpose of the Study:

  • To evaluate the efficacy of a novel
  • triple aspiration technique
  • in aspiration thrombectomy.
  • To compare the triple aspiration technique against single-syringe and continuous pump aspiration.
  • To assess outcomes including first-pass efficacy (FPE) and clot removal success.

Main Methods:

  • A 3D-printed adult vasculature model was used for benchtop testing.
  • Fibrin-rich and red blood cell-rich clots were artificially created.
  • Triple aspiration, single aspiration, and pump aspiration techniques were compared in a randomized fashion.

Main Results:

  • The triple aspiration technique demonstrated a significantly higher FPE rate (67.6%) compared to single (41.1%) and pump aspiration.
  • Complete clot removal was achieved with fewer attempts using triple aspiration (1.2) versus single aspiration (1.8).
  • Triple aspiration generated significantly higher vacuum pressures than both single-syringe and pump aspiration.

Conclusions:

  • The triple aspiration technique shows promise for improving FPE and vacuum pressure in aspiration thrombectomy.
  • Further clinical investigation is warranted to confirm the safety and efficacy of this technique.
  • This technique may offer an advantage in achieving successful clot retrieval.