Related Experiment Video
Updated: Jun 21, 2025
08:41
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
Published on: July 19, 2013
12.7K
Effect of spin-lock frequency on quantitative myocardial T1ρ mapping
Caiyun Han1, Huimin Xu1, Hui Gao1
1Department of Radiology, the First Affiliated Hospital of Anhui Medical University; Research Center of Clinical Medical Imaging; Anhui Province Clinical Image Quality Control Center, Hefei, 230032, Anhui Province, China.
Insights Into Imaging
|July 11, 2024
Summary
This study found that myocardial T1ρ values increase with spin-lock frequency and are higher in females. These findings help establish reference values for T1ρ mapping in cardiac magnetic resonance imaging.
Area of Science:
- Cardiovascular Magnetic Resonance Imaging
- Biomedical Engineering
- Medical Physics
Background:
- T1ρ mapping is a novel technique for assessing myocardial fibrosis.
- Understanding factors influencing T1ρ values is crucial for clinical application.
- Establishing reference values is necessary for accurate interpretation of T1ρ data.
Purpose of the Study:
- To investigate the influence of different spin-locking frequencies on myocardial T1ρ values.
- To provide reference T1ρ values for a 3.0-T MR system.
- To assess the impact of gender on myocardial T1ρ values.
Main Methods:
- Prospective study of 57 healthy subjects.
- T1ρ mapping performed on 3 short-axis slices.
- Three spin-lock frequencies (300, 400, 500 Hz) and varying durations were used.
- T1ρ relaxation times quantified and analyzed using statistical methods.
Main Results:
- Myocardial T1ρ values showed a significant progressive increase with higher spin-lock frequencies (p < 0.05).
- Females exhibited significantly higher T1ρ values compared to males across all frequencies (p < 0.05).
- Numerical differences in T1ρ values across frequencies were minimal.
Conclusions:
- Myocardial T1ρ values are influenced by spin-lock frequency and gender.
- Reference myocardial T1ρ values were established for specific CMR settings.
- Findings support the potential of T1ρ mapping for myocardial fibrosis detection.
![Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59399.jpg&w=3840&q=50)
Related Concept Videos
01:28Atomic Nuclei: Types of Nuclear Relaxation
286
Nuclear relaxation restores the equilibrium population imbalance and can occur via spin–lattice or spin–spin mechanisms, which are first-order exponential decay processes.
In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers...
In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers...
286
01:24Magnetic Resonance Imaging
5.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.1K
01:14Atomic Nuclei: Nuclear Spin State Population Distribution
971
Near absolute zero temperatures, in the presence of a magnetic field, the majority of nuclei prefer the lower energy spin-up state to the higher energy spin-down state. As temperatures increase, the energy from thermal collisions distributes the spins more equally between the two states. The Boltzmann distribution equation gives the ratio of the number of spins predicted in the spin −½ (N−) and spin +½ (N+) states.
971
01:05Atomic Nuclei: Magnetic Resonance
644
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
644
01:23Atomic Nuclei: Nuclear Relaxation Processes
644
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis, the precessing magnetic moments are randomly oriented around the z-axis.
644
01:14NMR Spectrometers: Resolution and Error Correction
683
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
683