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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Updated: Jun 21, 2025

Merkel Cell Polyomavirus Infection and Detection
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PRAME Expression in Merkel Cell Carcinoma.

Elisabeth Miller1, Andrew Biesemier1, David M Coomes2

  • 1Department of Pathology, University of Virginia, Charlottesville, VA.

The American Journal of Surgical Pathology
|July 12, 2024
PubMed
Summary
This summary is machine-generated.

Preferentially expressed antigen in melanoma (PRAME) expression in Merkel cell carcinoma (MCC) may indicate a worse prognosis. This study found PRAME positivity correlated with increased mortality risk in MCC patients, highlighting its potential prognostic value.

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive skin neuroendocrine tumor.
  • Risk factors include sun damage, Merkel cell polyomavirus (MCPyV), and immunosuppression.
  • Preferentially expressed antigen in melanoma (PRAME) is a cancer-testis antigen used in melanocytic neoplasms, but its role in MCC is unknown.

Purpose of the Study:

  • To investigate PRAME expression in MCC.
  • To explore the prognostic implications of PRAME in MCC patients.
  • To assess the correlation between PRAME expression and MCPyV positivity.

Main Methods:

  • Retrospective review of 39 MCC cases (2004-2022) at the University of Virginia.
  • Immunohistochemical staining for PRAME and MCPyV.
  • Cox proportional hazards regression models for survival analysis.

Main Results:

  • 28% of MCC cases showed strong PRAME expression; 27% were positive for MCPyV.
  • No significant correlation found between PRAME expression and MCPyV positivity.
  • Adjusted hazard ratio for all-cause mortality associated with PRAME positivity was 11.4 (95% CI: 1.8, 70.8).

Conclusions:

  • PRAME expression in MCC is associated with significantly worse all-cause mortality.
  • PRAME may serve as a valuable prognostic marker in Merkel cell carcinoma.
  • Further research is needed to validate these findings in larger cohorts.