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Updated: Jun 21, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Initial decrease in the lipoprotein(a) level is a novel prognostic biomarker in patients with acute coronary syndrome
Yasuhiko Saeki1, Jun Sawaguchi1, Satori Akita1
1Department of Cardiology, Kanazawa Medical University, Uchinada 9200293, Japan.
Lipoprotein(a) levels decrease after percutaneous coronary intervention in acute coronary syndrome patients. A larger Lp(a) drop indicates a worse prognosis for major adverse cardiac events.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Medicine
Background:
- Lipoprotein(a) [Lp(a)] is a known risk factor for atherosclerotic cardiovascular diseases.
- The specific role of Lp(a) in acute coronary syndrome (ACS) requires further clarification.
Purpose of the Study:
- To test if Lp(a) levels change during the acute phase of ACS.
- To determine if these changes correlate with subsequent cardiovascular events.
Main Methods:
- 377 ACS patients undergoing coronary angiography were analyzed.
- Lp(a) levels were measured before and up to 48 hours after percutaneous coronary intervention (PCI).
- Major adverse cardiac events (MACE) were tracked for a median of 1000 days.
Main Results:
- Lp(a) levels significantly decreased 12 hours post-PCI, then rose by 48 hours.
- The magnitude of Lp(a) decrease correlated with baseline creatinine and Lp(a) levels.
- A greater Lp(a) decrease was linked to higher MACE rates.
Conclusions:
- Emergent PCI in ACS patients causes a significant reduction in circulating Lp(a) levels.
- A pronounced decrease in Lp(a) post-PCI is an independent predictor of adverse cardiovascular outcomes.
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