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A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
Published on: June 8, 2018
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Consensus Guidelines of Irreversible Electroporation for Pancreatic Tumors: Protocol Standardization Using the
Danielle J W Vos1, Alette H Ruarus1, Florentine E F Timmer1
1Department of Radiology and Nuclear Medicine, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Seminars in Interventional Radiology
|July 12, 2024
Summary
Pancreatic irreversible electroporation (IRE) guidelines were established through expert consensus. These recommendations cover patient selection, treatment parameters, and follow-up for pancreatic cancer, aiming to standardize care.
Area of Science:
- Oncology
- Medical Physics
- Surgical Innovation
Background:
- Irreversible electroporation (IRE) is an emerging treatment for pancreatic malignancies.
- Lack of standardized protocols hinders comparative analysis of IRE outcomes in pancreatic cancer literature.
- This heterogeneity necessitates expert consensus to establish uniform treatment guidelines.
Purpose of the Study:
- To achieve expert consensus on patient selection, procedural parameters, and follow-up for pancreatic irreversible electroporation (IRE).
- To provide evidence-based recommendations for the safe and effective application of IRE in pancreatic cancer treatment.
- To reduce variability in current pancreatic IRE practices and facilitate outcome comparisons.
Main Methods:
- A modified Delphi technique involving 11 experts in pancreatic IRE.
- Anonymous, multi-round questionnaires to assess agreement on predefined criteria.
- Consensus defined as ≥80% agreement among participating experts.
Main Results:
- 93% consensus was reached across multiple rounds, with high initial response rates.
- Specific recommendations include IRE for Stage III pancreatic cancer and inoperable recurrent disease.
- Defined absolute contraindications, optimal inter-electrode distance (10-20 mm), exposure length (15 mm), pulse parameters (90 pulses, 90 µs, 1500 V/cm), and follow-up imaging schedule (1 month, then quarterly).
Conclusions:
- Expert consensus provides a framework for pancreatic IRE patient selection, procedure, and follow-up.
- Standardized guidelines are crucial for improving IRE efficacy and comparability in pancreatic cancer treatment.
- Further research is needed to define maximum tumor diameter, response evaluation criteria, and optimal neoadjuvant chemotherapy regimens.
