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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...

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FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Preimplantation genetic testing: A narrative review.

Sofia L E Fernandes¹, Filipa A G de Carvalho¹

¹Genetics-Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.

Porto Biomedical Journal

|July 12, 2024

Summary

Preimplantation genetic testing (PGT) aids in assisted reproduction by offering various diagnostic techniques. This review covers PGT indications, biopsy methods, and evolving technologies for better outcomes.

Keywords:

PGT-A PGT-M PGT-SR embryo selection preimplantation genetic testing

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Area of Science:

Reproductive Medicine
Genetics
Embryology

Background:

Preimplantation genetic testing (PGT) is integral to modern assisted reproduction.
Numerous indications and diverse techniques exist, requiring careful selection.
Understanding PGT's evolution is crucial for clinical application.

Purpose of the Study:

To review current indications for PGT.
To discuss various biopsy and diagnostic technologies used in PGT.
To explore the evolution and emerging methods in PGT.

Main Methods:

Review of scientific literature on PGT.
Analysis of biopsy techniques and diagnostic platforms.
Discussion of technological advancements and future trends in PGT.

Main Results:

PGT encompasses a range of techniques with specific advantages and limitations.
Indications for PGT are diverse, guiding the choice of diagnostic approach.
Technological evolution has enhanced PGT accuracy and scope.

Conclusions:

Careful consideration of PGT indications and available technologies is essential.
Ongoing advancements in biopsy and diagnostic methods are shaping the future of PGT.
Emerging PGT methods promise further improvements in reproductive outcomes.