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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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mRNA vaccine development and applications: A special focus on tumors (Review)

Bangjie Chen1, Yipin Yang1, Xinyi Wang2

  • 1Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

International Journal of Oncology
|July 12, 2024
PubMed

Insights

Messenger RNA (mRNA) vaccines offer a personalized approach to cancer therapy by stimulating immune responses against cancer cells. This review explores their development, function, and application in oncology.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Cancer's hallmarks include uncontrolled proliferation and metastasis, often leading to drug resistance.
  • Traditional cancer treatments face limitations, necessitating personalized therapeutic strategies.
  • Messenger RNA (mRNA) vaccine technology has advanced significantly, particularly post-pandemic.

Purpose of the Study:

  • To review the development and mechanisms of mRNA vaccines.
  • To discuss factors influencing mRNA vaccine efficacy.
  • To highlight the application of mRNA vaccines in personalized cancer therapy.

Main Methods:

  • Review of existing literature on mRNA vaccine development and cancer applications.
  • Analysis of mRNA vaccine mechanisms, including transcription and translation.
  • Discussion of clinical applications and challenges.

Main Results:

  • mRNA vaccines encode specific antigens, prompting targeted immune responses.
  • The technology enables personalized treatment by tailoring vaccines to individual tumors.
  • Recent progress has accelerated the adoption of mRNA vaccines in various fields, including oncology.

Conclusions:

  • mRNA vaccines represent a promising frontier in personalized cancer treatment.
  • Further research is needed to overcome challenges and optimize their use in oncology.
  • The adaptability of mRNA technology offers unique advantages for future cancer therapies.
Keywords:
applicationcancermRNA vaccinesmechanismprospects

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