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Updated: Jun 21, 2025

Extraction of Lignin with High β-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield
Published on: January 7, 2019
From Lignin to Value-Added Pharmaceutical Intermediates Based on a Benzylic Oxidation Method with O2
Heng Zhang1, Mengying Liu2, Zhehui Zhang2
1Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Abstract:
We present a catalytic strategy for converting lignin into various pharmaceutical intermediates based on a highly selective lignin depolymerization method and a green benzylic oxidation method employing O2. Selective depolymerization of lignin first afforded 4-ethylphenol, which then efficiently generates several pharmaceutical intermediates with a simple 5-step process, resulting in substantial economic benefits. The study provides an innovative solution for the efficient utilization of lignin and the green acquisition of pharmaceutical intermediates.
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