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Updated: Jun 21, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Discovery and characterization of small-molecule TGR5 ligands with agonistic activity

M Giovanna E Papadopoulos1, Alexander F Perhal2, Brian Medel-Lacruz3

  • 1Department of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany.

European Journal of Medicinal Chemistry
|July 12, 2024
PubMed

Keywords:
CRE-Luciferase assayMolecular dockingMolecular dynamics simulationsPAMStructure-based drug designTGR5

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