The Chromenopyridine Scaffold: A Privileged Platform in Drug Design
Fábio Pedroso de Lima1,2, Marta Costa3,4, Ana Sousa1,3,4
1Chemistry Centre, School of Sciences, University of Minho, Gualtar Campus, 4715-303 Braga, Portugal.
Abstract:
The chromenopyridine scaffold represents an important class of heterocyclic compounds exhibiting a broad spectrum of biological properties. This review describes novel and efficient procedures for the synthesis of this scaffold. Herein, several methods were detailed and grouped according to their starting material (e.g., salicylaldehydes, chromones, chromanones and coumarins) and respective biological activity, when reported. This review highlights the potential of the reported synthetic strategies for preparing chromenopyridine derivatives with promising biological activity, paving the way for further developments in drug discovery.
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