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Clinical and Physiological Variables in Patients with Post-COVID-19 Condition and Persistent Fatigue
Maércio Santos1, Mariana Dorna1, Estefânia Franco2
1São Paulo State University (Unesp), Medical School, Distrito de Rubião Junior s/n, Botucatu 18618-970, São Paulo, Brazil.
Journal of Clinical Medicine
|July 13, 2024
Summary
Post-COVID-19 condition with persistent fatigue is linked to increased dyspnea, anxiety, and reduced muscle strength. These factors significantly worsen quality of life in affected individuals.
Area of Science:
- Medical Research
- Pulmonology
- Neurology
Background:
- Post-COVID-19 condition presents diverse symptoms including dyspnea, cognitive issues, and fatigue.
- The underlying mechanisms of these symptoms, especially fatigue, require further investigation.
Purpose of the Study:
- To evaluate clinical and physiological factors in patients experiencing persistent fatigue after COVID-19.
- To compare patients with and without persistent fatigue one year post-infection.
Main Methods:
- Comprehensive evaluation of 77 patients one year after COVID-19 infection.
- Included assessments of blood count, metabolic panel, spirometry, dyspnea, quality of life, anxiety, depression, physical capacity, body composition, and muscle strength.
- Patients were divided into fatigue (G1) and non-fatigue (G2) groups.
Main Results:
- Patients with persistent fatigue (G1) reported greater dyspnea (BDI, mMRC scores) and worse quality of life (SGRQ score).
- Higher anxiety levels (HADS-A) and reduced peripheral and inspiratory muscle strength (handgrip, MIP) were observed in the fatigue group.
- Significant differences were noted in BDI (p<0.001), mMRC (p=0.002), SGRQ (p<0.001), HADS-A (p<0.001), handgrip (p=0.044), and MIP (p<0.001).
Conclusions:
- Persistent fatigue post-COVID-19 is associated with increased dyspnea, anxiety, reduced muscle strength, and impaired quality of life.
- Quality of life, anxiety levels, and peripheral muscle strength influence fatigue severity.
- Worsened quality of life correlates with greater dyspnea, lower muscle strength, and reduced physical capacity.
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