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Updated: May 6, 2026

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
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Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

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Morphological anomalies in obstructive hypertrophic cardiomyopathy: Insights from four-dimensional computed

Yuki Izumi1, Shuichiro Takanashi2, Mitsunobu Kitamura1

  • 1Hypertrophic Cardiomyopathy Center, Sakakibara Heart Institute, Tokyo, Japan; Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Journal of Cardiology
|July 13, 2024
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) involves complex anatomy beyond septal hypertrophy. Four-dimensional computed tomography (4D-CT) provides detailed morphological assessment for improved surgical planning in obstructive HCM.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease.
  • Left ventricular outflow tract (LVOT) obstruction significantly impacts HCM symptoms and prognosis.
  • Traditional understanding focused on septal hypertrophy, but other anomalies are now recognized.

Purpose of the Study:

  • To highlight the importance of comprehensive morphological assessment in obstructive HCM.
  • To evaluate the role of four-dimensional computed tomography (4D-CT) in characterizing complex HCM anatomy.
  • To demonstrate how detailed 4D-CT findings can guide septal reduction therapy.

Main Methods:

  • Review of recent evidence on HCM morphology.
  • Comparison of imaging modalities for assessing anomalous structures in HCM.
  • Application of 4D-CT for detailed evaluation of mitral valve, papillary muscles, and muscle bundles.
  • Utilizing 4D-CT for surgical planning in a specialized HCM center.

Main Results:

  • HCM involves complex anatomical variations including mitral valve and papillary muscle anomalies, and apical-basal muscle bundles.
  • Four-dimensional computed tomography offers superior spatial resolution and multiplanar capabilities for detailed morphological assessment.
  • 4D-CT enables precise evaluation of subaortic stenosis and right ventricular outflow tract obstruction.
  • Detailed 4D-CT assessment aids in planning surgical correction for obstructive HCM.

Conclusions:

  • Accurate morphological assessment is crucial for effective septal reduction therapy in obstructive HCM.
  • Four-dimensional computed tomography is a valuable tool for detailed anatomical evaluation in HCM.
  • Comprehensive 4D-CT-guided surgical planning may improve outcomes for patients with obstructive HCM.

Keywords:
Apical-basal muscle bundleComputed tomographyHypertrophic cardiomyopathyMitral valveSeptal reduction therapy

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