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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Updated: Jun 21, 2025

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Necroptosis and autoimmunity.

Lin Peng1

  • 1National Clinical Research Center for Kidney Disease, Affiliated Jinling Hospital, Medical School of Nanjing University, Zhongshan East Road No.305, Nanjing, Jiangsu 210002, China.

Clinical Immunology (Orlando, Fla.)
|July 13, 2024
PubMed
Summary
This summary is machine-generated.

Necroptosis, a form of inflammatory cell death, plays a role in maintaining immune homeostasis. Dysregulation can contribute to autoimmune diseases, highlighting its complex involvement in immunity.

Keywords:
Autoimmune diseaseMacrophageNecroptosisRHIM interactionT cells

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Autoimmunity involves maintaining immunological homeostasis and surveillance.
  • Necroptosis is a regulated inflammatory cell death pathway.
  • Immune responses to necroptosis can either resolve inflammation or promote autoimmune disease.

Purpose of the Study:

  • To review the role of necroptosis in autoimmunity.
  • To discuss necroptosis mechanisms, focusing on RIP homotypic interaction motif (RHIM) interactions.
  • To explore the cell biology of necroptosis in the context of autoimmune diseases.

Main Methods:

  • Literature review of necroptosis.
  • Analysis of RIPK1-RIPK3-MLKL necrosome complex formation.
  • Examination of necroptosis involvement in physiological and pathological conditions.

Main Results:

  • Necroptosis, regulated by the RIPK1-RIPK3-MLKL necrosome, is critical for immune homeostasis.
  • The outcome of necroptosis influences the progression or resolution of inflammatory conditions.
  • Understanding necroptosis mechanisms is key to its potential application in autoimmune diseases.

Conclusions:

  • Necroptosis is intricately linked to the balance of immune responses.
  • Aberrant necroptosis signaling can contribute to the development of autoimmune disorders.
  • Targeting necroptosis pathways may offer therapeutic strategies for autoimmune diseases.