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Updated: Jul 21, 2026
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Factors affecting choroidal circulation parameters in 4-14-year-old Chinese children measured by SS-OCT/OCTA
Haoming Geng1, Jingyu Mu2, Juan Wen3
1Chengdu University of TCM, Chengdu, Sichuan, China; Eye college of Chengdu University of TCM, Chengdu, Sichuan, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM Laboratory, Chengdu, Sichuan, China.
Insights
Choroidal vascular volume and stromal volume decrease with longer axial length in children. Choroidal vascularity index increases with age after 8 years, correlating with choroidal thickness.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Optical Coherence Tomography Imaging
Background:
- Choroidal circulatory parameters are crucial for ocular health.
- Understanding these parameters in children is essential for monitoring eye development and detecting potential issues.
Purpose of the Study:
- To measure choroidal circulatory parameters in Han Chinese children aged 4-14 years.
- To investigate the relationship between these parameters and age, axial length (AL), and choroidal thickness (ChT).
Main Methods:
- A cross-sectional study included 284 eyes from 142 children.
- Cycloplegic refraction and IOLMaster500 examination were performed.
- Swept-source optical coherence tomography (SS-OCT) assessed submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.
Main Results:
- Mean CVV was 2.92 mm³, CSV was 4.69 mm³, CVI was 38.22%, and CVV/CSV ratio was 62.11%.
- CVV and CSV were negatively correlated with AL and positively correlated with ChT (P < 0.001).
- CVI correlated positively with age after 8 years (P < 0.01) and with ChT (P < 0.01).
Conclusions:
- Age positively correlates with CVI after 8 years.
- Choroidal thickness (ChT) is well correlated with CVI.
- Longer AL and thinner ChT are linked to reduced CVV and CSV, with CVV declining faster than CSV.
Purpose:
To measure the choroidal circulatory parameters Han Chinese children aged 4-14 years from Southwest China, and to explore the relationships between these parameters and age, axial length (AL), and choroidal thickness (ChT).
Methods:
284 eyes from 142 subjects were included in this cross-sectional study. All participants underwent cycloplegic refraction and IOLMaster500 examination. Swept-source optical coherence tomography (SS-OCT) was used to measure submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.
Results:
In this population, the mean CVV was 2.92 ± 0.55 mm3, CSV was 4.69 ± 0.68 mm3, CVI was 38.22 ± 2.46 %, and CVV/CSV ratio was 62.11 ± 6.44 %. Multivariable regression analyses showed that both CVV and CSV were negatively correlated with AL (both P < 0.001) and positively correlated with ChT (both P < 0.001), while age showed no significant correlation with them (both P > 0.05). However, the correlations between CVI and age were not uniform rectilinear. Among participants aged ≤8 years, CVI showed no correlation with age (P > 0.05), while among those aged >8 years, it was positively correlated with age (P < 0.01). CVV/CSV ratio was positively correlated with ChT and age (both P < 0.01).
Conclusion:
After the age of 8, age was positively correlated with CVI. ChT was well correlated with CVI. Longer AL and thinner ChT were associated with reduced CVV and CSV, with CVV decreasing more rapidly than CSV.
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