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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Jun 21, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

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High-intensity interval training improves bone remodeling, lipid profile, and physical function in multiple sclerosis

Alessandra Amato1, Patrizia Proia2, Anna Alioto3

  • 1Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Science, School of Medicine, University of Catania, Via S. Sofia No 97, 95123, Catania, Italy.

Scientific Reports
|July 13, 2024
PubMed
Summary

High-intensity interval training (HIIT) significantly improved neuromotor abilities, bone formation, and lipid profiles in multiple sclerosis (MS) patients over 8 weeks. This exercise intervention offers a promising approach for managing MS symptoms and improving overall health.

Keywords:
Adapted physical activityBiochemistry parametersBone markersCoordinationMultiple sclerosisMuscle physiologySportTraining

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Area of Science:

  • Neurology
  • Exercise Physiology
  • Metabolic Health

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, demyelinating, and neurodegenerative disease with incompletely understood etiology.
  • Physical activity is recognized for its crucial role in enhancing the quality of life for individuals with neuropathological conditions.

Purpose of the Study:

  • To investigate the potential benefits of high-intensity interval training (HIIT) on bone and lipid metabolism markers.
  • To assess the impact of HIIT on neuromotor abilities in patients with multiple sclerosis.

Main Methods:

  • 16 participants with MS were randomized into a control group (no exercise) and an exercise group (HIIT).
  • The exercise group underwent a 3-times-weekly, 8-week remote HIIT protocol supervised by a kinesiologist.
  • Physical function tests, bone remodeling markers, and lipid profiles were measured at baseline (T0) and post-intervention (T1).

Main Results:

  • Significant improvements were observed in wall squat and Time Up and Go test performances, indicating enhanced lower limb strength and gait control.
  • Lipid profiles showed a significant reduction in Total and LDL cholesterol levels.
  • Bone metabolism markers demonstrated an increase in osteocalcin (bone formation) and improved 25-OH Vitamin D levels.

Conclusions:

  • Eight weeks of HIIT positively impacted lower limb strength and gait control in MS patients.
  • HIIT demonstrated benefits in improving bone formation markers and managing lipid profiles.
  • The study suggests HIIT is a viable intervention for enhancing physical function and metabolic health in individuals with multiple sclerosis.