Related Experiment Video

Updated: Jun 21, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.1K

Basic implications on three pathways associated with SARS-CoV-2

Jong Hoon Lee1, Consolato Sergi2, Richard E Kast3

  • 1Science and Research Center, Seoul National University College of Medicine, Seoul, South Korea.

Biomedical Journal
|July 14, 2024
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multiorgan impacts through host-virus interactions. Understanding pathways like ACE2, TLR, and NRP is key to developing future therapies targeting innate lymphoid cells against SARS-CoV-2 variants.

Area of Science:

  • Virology
  • Immunology
  • Pathophysiology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to complex host-virus interactions.
  • These interactions result in significant multiorgan impacts, highlighting the systemic nature of the disease.
  • Understanding the molecular mechanisms underlying these impacts is crucial for effective treatment strategies.

Purpose of the Study:

  • To elucidate the key host-virus interaction pathways involved in SARS-CoV-2 pathophysiology.
  • To identify critical molecular targets for therapeutic intervention.
  • To explore the potential of modulating innate lymphoid cells for future coronavirus variant control.

Main Methods:

  • Analysis of host-virus interaction mechanisms.
  • Investigation of the angiotensin-converting enzyme (ACE2), Toll-like receptor (TLR), and neuropilin (NRP) pathways.
  • Exploration of the spike protein pathway's role.

Main Results:

  • Identified the involvement of ACE2, TLR, and NRP pathways in SARS-CoV-2 pathogenesis.
  • Highlighted the critical role of the spike protein pathway.
  • Established the link between these pathways and multiorgan damage.

Conclusions:

  • Blocking the pathological course of SARS-CoV-2 requires targeting specific host-virus interaction pathways.
  • Modulating innate lymphoid cells presents a promising strategy for future therapeutic development against diverse coronavirus variants.
  • Further research into these pathways is essential for pandemic preparedness.
Keywords:
ACE2COVID-19SARS-CoV-2Spike proteinTLR

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.1K

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.4K
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.8K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.8K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K