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Updated: Jun 21, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Complement system molecules: Expression and regulation at the maternal-conceptus interface during pregnancy in pigs.

Soohyung Lee¹, Inkyu Yoo¹, Yugyeong Cheon¹

¹Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.

Developmental and Comparative Immunology

|July 14, 2024

Summary

The complement system is vital for innate immunity. This study reveals its crucial role in pig pregnancy, impacting maternal immune regulation for successful gestation.

Keywords:

Complement Endometrium Implantation Pig Pregnancy

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Area of Science:

Reproductive immunology
Innate immunity
Complement system biology

Background:

The complement system is essential for innate immunity.
Its dysregulation is linked to adverse pregnancy outcomes in humans and rodents.
Its role in pigs at the maternal-conceptus interface remains uninvestigated.

Purpose of the Study:

To investigate the expression, localization, and regulation of complement system molecules at the maternal-conceptus interface in pigs.
To understand the role of the complement system in establishing and maintaining pregnancy in pigs.

Main Methods:

Investigated expression and localization of complement components and control proteins in endometrial, conceptus, and chorioallantoic tissues.
Analyzed changes in expression during pregnancy compared to the estrous cycle.
Examined regulation by interferon-gamma (IFNG) in endometrial explants.
Detected cleaved C3 fragments in tissues and uterine flushings.

Main Results:

Complement molecules are expressed in porcine maternal-conceptus interface tissues.
Expression of early complement activators increased in the endometrium during pregnancy.
Cell-type specific localization of complement proteins was observed.
Interferon-gamma upregulated specific complement genes.
Increased levels of cleaved C3 fragments were found during pregnancy.

Conclusions:

Complement system molecules are present and regulated at the maternal-conceptus interface in pigs.
These molecules likely play a significant role in innate immunity and modulating the maternal immune environment during pregnancy.
Findings suggest a role in the establishment and maintenance of pregnancy in pigs.