Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

193
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
193
Drug Delivery: Overview01:16

Drug Delivery: Overview

285
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
285
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

794
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
794
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

128
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
128
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

1.3K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.3K
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

255
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
255

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Nonionizing Millimeter-Wave on Spheroid-like Irradiated Non-Small-Cell Lung Cancer (NSCLC) Cells.

International journal of molecular sciences·2026
Same author

Genetically engineered <i>Spirulina plantensis</i> producing human insulin as a potential novel oral drug delivery carrier.

Biomaterials science·2026
Same author

The Selective in vitro Cytotoxicity of <i>Spirulina</i>-Derived Nanoparticles: A Novel Biomimetic Approach to Cancer Therapy.

International journal of nanomedicine·2025
Same author

An In vitro Caco2-Based Model for Measuring Intestinal Bioadhesion Comparable to Ex vivo Models.

Small science·2025
Same author

Natural Epithelial Barrier Integrity Enhancers-<i>Citrus medica</i> and <i>Origanum dayi</i> Extracts.

Gels (Basel, Switzerland)·2024
Same author

In vitro Models for Predicting Bioadhesion Fracture Strength to Ex Vivo Animal Buccal Tissue.

Small (Weinheim an der Bergstrasse, Germany)·2024

Related Experiment Video

Updated: Jun 21, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K

A Review: Surface Engineering of Lipid-Based Drug Delivery Systems.

Dhaval Patel1, Jyoti Solanki2, Mafatlal M Kher1

  • 1Department of Chemical Engineering and Biotechnology, Ariel University, Ariel, 4070000, Israel.

Small (Weinheim an Der Bergstrasse, Germany)
|July 15, 2024
PubMed
Summary

Surface modification enhances lipid-based nanoparticles (LBNPs) for drug delivery. This review details advancements in modifying LBNPs and cell membrane-based nanoparticles (CMNPs) for improved targeting and biocompatibility.

Keywords:
biomimetic nanoparticlescell membrane‐based drug deliverydrug deliverylipidsliposomesnanocarrierssurface modification

More Related Videos

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
09:45

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

2.6K
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.0K

Related Experiment Videos

Last Updated: Jun 21, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K
On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
09:45

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

2.6K
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.0K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Lipid-based nanoparticles (LBNPs) are crucial for drug delivery (DD).
  • Conventional LBNPs face challenges like poor targeting, rapid clearance, and limited biocompatibility.
  • Surface modification offers a promising strategy to overcome these limitations.

Purpose of the Study:

  • To review the evolution and advancements in surface modification of LBNPs for drug delivery.
  • To explore cell membrane-based nanoparticles (CMNPs) and biomimetic hybrid nanoparticles for enhanced DD.
  • To provide a comprehensive resource for researchers in lipid-based DD systems.

Main Methods:

  • Classification of LBNPs into liposomes and CMNPs.
  • Analysis of various surface modification materials (e.g., PEG, aptamers, peptides, natural ligands).
  • Exploration of CMNPs derived from various cell types (RBCs, platelets, leukocytes, cancer cells, stem cells).
  • Discussion of biomimicking hybrid nanoparticles via cell membrane coating.

Main Results:

  • Surface modification significantly enhances LBNP properties, including mass transport, immune evasion, stability, and targeting.
  • CMNPs leverage natural cell properties like biocompatibility and immune evasion for effective DD.
  • Biomimetic hybrid nanoparticles combine synthetic NP advantages with cell membrane benefits.

Conclusions:

  • Surface modification and the use of CMNPs represent key advancements in lipid-based drug delivery.
  • These strategies offer improved therapeutic efficacy and reduced side effects.
  • The review highlights the dynamic progress and future directions in lipid-based DD systems.