Delivery of mRNA Using Biomimetic Vectors: Progress and Challenges

Area of Science:

• Biomedical Engineering
• Therapeutic Delivery Systems
• Molecular Medicine

Background:

• Messenger RNA (mRNA) represents a promising therapeutic modality for diverse diseases.
• The clinical application of mRNA is hindered by its inherent instability and inefficient cellular uptake.
• Effective delivery systems are crucial for in vivo mRNA expression in target cells and tissues.

Purpose of the Study:

• To review biomimetic vector-based strategies for mRNA delivery.
• To discuss the advantages of biomimetic vectors over conventional delivery systems.
• To explore the challenges and future prospects of biomimetic mRNA delivery systems in the biomedical field.

Main Methods:

• Literature review of biomimetic vector-based mRNA delivery systems.
• Analysis of the properties and advantages of biomimetic vectors (biocompatibility, targeting).
• Discussion of current challenges and future directions in the field.

Main Results:

• Biomimetic vectors demonstrate high biocompatibility and tissue-specific targeting capabilities.
• These vectors show potential for efficient in vivo mRNA delivery, overcoming limitations of naked mRNA.
• The review synthesizes existing knowledge on biomimetic approaches for mRNA therapeutics.

Conclusions:

• Biomimetic vectors are a promising strategy for overcoming mRNA delivery hurdles.
• Further research into biomimetic vector design and application can significantly advance mRNA-based therapies.
• This review provides insights into the potential and challenges of biomimetic systems for future biomedical applications.