Electrophysiologic evaluation of patients with multiple sclerosis

In patients with suspected MS but clinical evidence for only a single lesion, electrophysiologic studies may provide evidence for subclinical involvement elsewhere in the CNS, thereby helping to establish the diagnosis with greater confidence. They may also provide objective evidence of neurologic dysfunction in patients with nonspecific symptoms whose true nature is not otherwise apparent. The possible role and limitations of electrophysiologic techniques in following the course of MS is discussed.