Repeatability of Automatic Measurements by an Anterior Segment Swept-Source OCT Biometer in Patients With Keratoconus

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optometry

Background:

• Keratoconus diagnosis and management rely on accurate anterior segment measurements.
• Assessing the performance of new diagnostic devices is crucial for clinical adoption.

Purpose of the Study:

• Evaluate the repeatability of the ANTERION anterior segment optical coherence tomographer.
• Compare ANTERION measurements with the MS-39 device in keratoconus patients.

Main Methods:

• Fifty-four keratoconus patients were enrolled.
• Repeatability assessed using standard deviation, coefficient of variation (CoV), and intraclass correlation coefficient (ICC).
• Agreement analyzed using Bland-Altman plots and paired t-tests.

Main Results:

• ANTERION demonstrated high repeatability (ICC > 0.98) and low CoV (<5% for astigmatism).
• Significant differences observed in corneal power and posterior keratometry between ANTERION and MS-39.
• Moderate agreement for simulated keratometry, but poor agreement for total corneal power and posterior keratometry.

Conclusions:

• The ANTERION device exhibits excellent repeatability for anterior segment analysis in keratoconus.
• While showing good agreement for some parameters, the ANTERION and MS-39 are not interchangeable for all measurements.
• Further validation is needed for specific clinical applications.