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Pleural Effusion II: Symptoms and Management01:28

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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
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Pleural Effusion I: Introduction01:25

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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
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Updated: Jun 21, 2025

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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[Treatment of malignant effusion].

L A Efteev1, Yu S Esakov1, E V Blinova2

  • 1Clinical Oncological Hospital N. 1, Moscow, Russia.

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Summary

Malignant pleural effusion, common in advanced cancers, worsens prognosis and quality of life. This study analyzes treatments for recurrent malignant pleural effusion, evaluating efficacy and recurrence risk.

Keywords:
malignant effusionpleural drainagepleurectomypleurodesis

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Area of Science:

  • Oncology
  • Thoracic Medicine
  • Palliative Care

Background:

  • Malignant effusion affects over 15% of advanced cancers.
  • Common causes include lung, breast, ovarian cancers, and gastrointestinal tumors.
  • It negatively impacts survival, quality of life, and treatment management.

Purpose of the Study:

  • To analyze and compare conservative and surgical treatment methods for recurrent malignant pleural effusion.
  • To evaluate the efficacy, recurrence rates, and reproducibility of different treatment strategies.

Main Methods:

  • Review and analysis of existing conservative and surgical treatment modalities for malignant pleural effusion.
  • Comparative assessment of treatment outcomes, focusing on efficacy and recurrence risk.

Main Results:

  • Malignant effusion significantly complicates advanced cancer progression and patient outcomes.
  • Current treatment strategies for recurrent malignant pleural effusion lack a uniform approach.
  • Analysis focused on efficacy, recurrence, and reproducibility of various obliteration methods.

Conclusions:

  • Recurrent malignant pleural effusion presents a significant clinical challenge in advanced cancer care.
  • A standardized approach to treatment selection is still needed.
  • Further research is required to optimize management strategies for improved patient outcomes.