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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
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Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
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Related Experiment Video

Updated: Jun 21, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Seasonal Variations in Stroke Occurrence.

Vincent Brissette1, Moira K Kapral2,3, Bing Yu3

  • 1Division of Neurology, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Neuroepidemiology
|July 15, 2024
PubMed
Summary
This summary is machine-generated.

Seasonal variations in stroke occurrence and case fatality were observed, with winter showing a higher risk of fatality. Understanding these trends can help tailor healthcare resources to peak needs.

Keywords:
Administrative dataSeasonal variationsStroke occurrenceStroke subtypes

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Area of Science:

  • Neurology
  • Public Health
  • Epidemiology

Background:

  • Seasonal variations in stroke incidence and outcomes are not fully understood.
  • Identifying these patterns can inform resource allocation and public health strategies.
  • This study aimed to investigate seasonal trends in stroke occurrence and fatality.

Purpose of the Study:

  • To evaluate seasonal variations in the occurrence of stroke and its subtypes.
  • To assess seasonal differences in 30-day case fatality risk for stroke patients.

Main Methods:

  • Retrospective cohort study utilizing Canadian administrative health data (2003-2017).
  • Analysis of age/sex standardized rates and adjusted rate ratios for stroke occurrence by season.
  • Cox proportional hazard models used to assess the effect of season on 30-day stroke case fatality.

Main Results:

  • A total of 394,145 stroke or transient ischemic attack (TIA) events were recorded.
  • Stroke occurrence was slightly lower in fall and winter compared to summer.
  • Winter was associated with the highest risk of 30-day stroke case fatality (aHR 1.10).

Conclusions:

  • Significant seasonal variations exist in stroke occurrence and case fatality.
  • While absolute differences were small, winter poses a higher fatality risk.
  • Further research into environmental and meteorological factors influencing stroke risk is warranted.