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Life's Essential 8, Genetic Susceptibility, and Incident Cardiac Arrhythmias: A Population-Based Prospective Cohort

Da-Chuan Guo1, Zhi-Teng Chen2, Xiang Wang3

  • 1Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The Canadian Journal of Cardiology
|July 15, 2024
PubMed

Insights

Maintaining ideal cardiovascular health (CVH) significantly lowers the risk of developing atrial fibrillation, ventricular arrhythmias, and bradyarrhythmias. Adopting healthier lifestyle choices, as measured by Life's Essential 8 (LE8) metrics, is crucial for preventing cardiac arrhythmias.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Public Health

Background:

  • Ideal cardiovascular health (CVH) is linked to reduced cardiovascular disease (CVD) risk.
  • The association between CVH and cardiac arrhythmias remained unclear.
  • This study investigated CVH's impact on arrhythmias like atrial fibrillation (AF), ventricular arrhythmias, and bradyarrhythmias.

Purpose of the Study:

  • To examine the relationship between cardiovascular health and the risk of developing cardiac arrhythmias.
  • To determine if higher levels of CVH are associated with lower incidence of AF, ventricular arrhythmias, and bradyarrhythmias.
  • To assess the impact of Life's Essential 8 (LE8) metrics on arrhythmia risk.

Main Methods:

  • Prospective cohort study utilizing UK Biobank data from 287,264 participants.
  • Cox regression models analyzed the association between CVH levels (LE8 metrics) and cardiac arrhythmias.
  • Participants were initially free of arrhythmias.

Main Results:

  • Over 12.8 years, 16,802 incident AF, 2186 ventricular arrhythmias, and 4128 bradyarrhythmias were recorded.
  • High CVH levels were associated with significantly lower risks for AF (HR 0.63), ventricular arrhythmias (HR 0.48), and bradyarrhythmias (HR 0.64).
  • Each SD increase in LE8 scores reduced AF risk by 15%, ventricular arrhythmias by 21%, and bradyarrhythmias by 13%.

Conclusions:

  • Higher levels of CVH, assessed by LE8 metrics, are significantly associated with reduced risks of AF, ventricular arrhythmias, and bradyarrhythmias.
  • Maintaining ideal cardiovascular health is a protective factor against developing common cardiac arrhythmias.
  • The findings underscore the importance of promoting CVH for arrhythmia prevention.
Abstract

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