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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Cerebrospinal fluid HIV RNA escape syndrome
Sian Nasse1, Jonathan Underwood2,3, Tom A T Hughes4
1Neurology, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK Sian.Nasse@doctors.org.uk.
Abstract:
A 54-year-old man with treated HIV developed a subacute deterioration of speech, mobility and cognition. Cerebrospinal fluid (CSF) analysis showed a raised protein and a discordant CSF HIV RNA paired with plasma HIV RNA, confirming the diagnosis of CSF HIV RNA escape syndrome. It is important to consider this diagnosis in people with treated HIV who develop new neurological symptoms.
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