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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Jun 21, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Imaging Tumor Metabolism.

Thomas Ruan1, Kayvan R Keshari2,3,4

  • 1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Cold Spring Harbor Perspectives in Medicine
|July 15, 2024
PubMed
Summary
This summary is machine-generated.

Molecular imaging allows in vivo study of cancer metabolism. Positron emission tomography (PET) and magnetic resonance (MR) are key techniques for understanding tumor biology and guiding treatment.

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Area of Science:

  • Oncology
  • Molecular Imaging
  • Biochemistry

Background:

  • Cancer metabolism is complex and spatially heterogeneous.
  • Understanding in vivo cancer metabolism is crucial for diagnosis and treatment.
  • Molecular imaging offers unique insights into cellular and molecular processes within tumors.

Purpose of the Study:

  • To review the application of molecular imaging in cancer metabolism.
  • To discuss the capabilities of Positron Emission Tomography (PET) and Magnetic Resonance (MR) for metabolic imaging.
  • To highlight the strengths and limitations of current molecular imaging strategies for cancer.

Main Methods:

  • Review of Positron Emission Tomography (PET) techniques for metabolic imaging.
  • Review of Magnetic Resonance (MR) techniques for metabolic imaging.
  • Analysis of molecular imaging's ability to probe specific metabolic pathways (e.g., glycolysis, glutamine metabolism).

Main Results:

  • PET and MR are established modalities for in vivo metabolic imaging in cancer.
  • These techniques can assess glycolysis, glutamine metabolism, anabolic processes, redox state, hypoxia, and extracellular pH.
  • Current strategies provide valuable, albeit sometimes limited, insights into tumor metabolism.

Conclusions:

  • Molecular imaging, particularly PET and MR, is essential for interrogating cancer metabolism in vivo.
  • These modalities offer a spatial context for understanding tumor biology.
  • Further development of molecular imaging strategies is needed to overcome current limitations.