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Association between the atherogenic index of plasma and coronary collateral circulation in patients with chronic

Shutong Dong1, Jiaming Qiao1, Ang Gao1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Beijing, 100029, China.

BMC Cardiovascular Disorders
|July 15, 2024
PubMed

Insights

High atherogenic index of plasma (AIP) is linked to poor coronary collateral circulation (CCC) in coronary artery disease (CAD) patients with chronic total occlusion (CTO). AIP may improve identification of poor CCC in clinical practice.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) poses a significant health burden globally.
  • Coronary collateral circulation (CCC) plays a crucial role in mitigating ischemic damage in CAD.
  • Chronic total occlusion (CTO) presents a complex challenge in CAD management.

Purpose of the Study:

  • To investigate the association between the atherogenic index of plasma (AIP) and the formation of CCC in CAD patients with CTO.
  • To determine if AIP is an independent predictor of poor CCC in this patient cohort.

Main Methods:

  • Retrospective analysis of 1093 CAD patients with CTO undergoing coronary angiography.
  • Classification of patients into good and poor CCC groups based on the Rentrop scoring system.
  • Calculation of AIP using the formula: log (triglyceride/high-density lipoprotein cholesterol).

Main Results:

  • Patients with poor CCC exhibited significantly higher AIP compared to those with good CCC (p < 0.001).
  • Multivariate logistic regression confirmed an independent association between elevated AIP and poor CCC (p < 0.001).
  • Inclusion of AIP improved the accuracy in identifying poor CCC (AUC increased from 0.661 to 0.721).

Conclusions:

  • Elevated AIP is independently associated with an increased risk of poor CCC in CAD patients with CTO.
  • AIP demonstrates potential as a valuable biomarker for identifying patients with suboptimal collateralization.
  • These findings suggest AIP could enhance clinical risk stratification and treatment strategies for CTO patients.
Abstract

Keywords:
Atherogenic index of plasmaChronic total occlusionCoronary artery diseaseCoronary collateral circulationHigh-density lipoprotein cholesterolTriglyceride

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