The Cancer Clinical Library Database (CCLD) from the Korea-Clinical Data Utilization Network for Research Excellence...

Area of Science:

• Oncology
• Biomedical Informatics
• Data Science

Background:

• Common data models (CDMs) are widely used in healthcare but have limited application in cancer research.
• Standardized cancer-specific databases are needed to facilitate robust multicenter cancer studies.

Purpose of the Study:

• To describe the development and implementation of Cancer Clinical Library Databases (CCLDs) in Korea.
• To establish a standardized cancer data resource for research under the Korea-Clinical Data Utilization Network for Research Excellence (K-CURE) project.

Main Methods:

• Fifteen hospitals and fourteen academic associations are constructing CCLDs for 10 cancer types.
• Experts define and standardize key clinical data items, creating a unified schema.
• Comprehensive patient data (diagnosis, treatment, outcomes) are collected annually with Six Sigma quality control.

Main Results:

• CCLDs are being developed for 10 primary cancer types across leading Korean institutions.
• Data security is ensured through pseudonymization and a closed analysis environment.
• A K-CURE portal facilitates researcher access pending IRB and Data Review Board approval.

Conclusions:

• CCLDs represent a pioneering, standardized cancer-specific database in Korea.
• This initiative is expected to overcome limitations of existing CDMs.
• CCLDs will provide a valuable resource for multicenter cancer research in Korea.