Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.0K
RNA Editing02:23

RNA Editing

9.0K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.0K
CRISPR01:59

CRISPR

50.4K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
50.4K
What is Genetic Engineering?00:49

What is Genetic Engineering?

74.0K
Overview
74.0K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.6K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuron-specific epigenetic repression of <i>Cdk5</i> impairs hippocampal-dependent memory in male and female mice.

bioRxiv : the preprint server for biology·2026
Same author

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses.

Neuron·2026
Same author

Hippocampal Cdk5 is regulated by distinct stress paradigms in male and female mice.

bioRxiv : the preprint server for biology·2026
Same author

Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memory.

bioRxiv : the preprint server for biology·2025
Same author

Epigenetic editing: from concept to clinic.

Nature reviews. Drug discovery·2025

Related Experiment Video

Updated: Jun 21, 2025

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

769

Neuroepigenetic Editing.

Peter J Hamilton1, Carissa J Lim2, Eric J Nestler3

  • 1Department of Anatomy & Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|July 16, 2024
PubMed
Summary
This summary is machine-generated.

Neuroepigenetic editing tools are crucial for understanding brain function and neurological diseases. These advanced methods help determine the functional relevance of epigenetic modifications, paving the way for new therapies.

Keywords:
Epigenetic editingchromatinneurosciencepsychiatric disease

More Related Videos

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.5K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

33.8K

Related Experiment Videos

Last Updated: Jun 21, 2025

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

769
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.5K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

33.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Epigenetic regulation is fundamental to brain function and neurological disorders.
  • Chromatin-modifying enzymes in the brain are vital during development, adulthood, and in response to stimuli.
  • Next-generation sequencing (NGS) studies globally assess gene expression and epigenetic modifications in brain cells.

Purpose of the Study:

  • To review current advances in neuroepigenetic editing tools.
  • To highlight methodological considerations for neuroscience applications.
  • To demonstrate the potential of epigenetic editing in neurobiology and therapeutics.

Main Methods:

  • Discussion of neuroepigenetic editing tools.
  • Analysis of methodological considerations including delivery methods.
  • Evaluation of spatiotemporal specificity in editing.

Main Results:

  • Neuroepigenetic editing is essential for discerning the functional impact of epigenetic modifications.
  • Methodological considerations such as delivery and specificity are critical for neuroscience.
  • Epigenetic editing shows significant potential for research and therapeutic applications.

Conclusions:

  • Neuroepigenetic editing tools are indispensable for advancing our understanding of the brain.
  • Effective application requires careful consideration of delivery and spatiotemporal control.
  • Epigenetic editing holds immense promise for both fundamental neurobiological research and clinical interventions.