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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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A Protocol for Computer-Based Protein Structure and Function Prediction
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A modular inquiry-based semester theme that integrates data science education and bioinformatics in protein structure

Zareen Amtul1, Forough Firoozbakht2, Iman Rezaeian2

  • 1Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, Canada.

FEMS Microbiology Letters
|July 16, 2024
PubMed
Summary

This study integrated bioinformatics activities into a graduate protein structure course, enhancing students' skills in analyzing biological data. Positive feedback and performance indicate improved bioinformatics knowledge for future careers.

Keywords:
BioinformaticsChimeraamino acid sequencehomology modelingnucleotide sequencepedagogy

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Area of Science:

  • Biotechnology
  • Computational Biology
  • Genomics

Background:

  • Bioinformatics skills are in high demand across academia and industry due to exponential data growth.
  • There is a critical need to enhance students' bioinformatics competencies for data science careers.
  • The field of bioinformatics faces a supply shortage relative to its demand.

Purpose of the Study:

  • To integrate practical bioinformatics activities into a graduate-level protein structure and function course.
  • To provide students with hands-on experience in analyzing biomolecular and structural biology data.
  • To assess the impact of inquiry-based bioinformatics exercises on student learning and skill development.

Main Methods:

  • Implemented semester-long, inquiry-based bioinformatics exercises focusing on biomolecular data analysis.
  • Incorporated hands-on activities within a protein structure and function graduate course.
  • Students completed a final project identifying unknown proteins using acquired bioinformatics knowledge.

Main Results:

  • Post-module surveys and lab performance indicated enhanced in-depth knowledge of bioinformatics.
  • Students with limited prior bioinformatics experience reported positive feedback on the module.
  • The module effectively improved students' understanding and application of bioinformatics tools.

Conclusions:

  • Students gained familiarity with cross-indexed databases for proteins, enzymes, and genes.
  • The research-based pedagogical approach equipped students with essential bioinformatics skillsets.
  • This training empowers students for future endeavors in the rapidly growing bioinformatics field.