Association between mpMRI detected tumor apparent diffusion coefficient and 5-year biochemical recurrence risk after...

Area of Science:

• Radiology
• Oncology
• Urology

Background:

• Prostate cancer (PCa) management often involves radical prostatectomy (RP).
• Predicting biochemical recurrence (BCR) post-RP is crucial for patient management.
• Multiparametric magnetic resonance imaging (mpMRI) offers insights into tumor characteristics.

Purpose of the Study:

• To evaluate the predictive capability of tumor apparent diffusion coefficient (ADC) values from mpMRI for 5-year BCR risk after RP.
• To determine if ADC values can serve as a prognostic biomarker in prostate cancer patients.

Main Methods:

• Retrospective analysis of 1439 prostate cancer patients undergoing RP.
• mpMRI was performed before RP, with tumor ADC values assessed.
• ADC was analyzed continuously and categorized (low, intermediate, high).
• Kaplan-Meier analysis and Cox regression models were used to assess BCR risk.

Main Results:

• Lower tumor ADC values were significantly associated with a higher risk of 5-year BCR in peripheral zone PCa.
• Patients with low ADC values had a 5-year BCR-free survival rate of 52.3%, compared to 87% for high ADC.
• No significant association between ADC and BCR was found in non-peripheral zone PCa patients.

Conclusions:

• Tumor ADC values are predictive of 5-year BCR risk following RP in peripheral zone prostate cancer.
• ADC measurements from mpMRI can potentially be utilized as a prognostic biomarker for recurrence after RP.